I’d never realized how convenient/natural a joystick is for adjusting your side mirrors. I’m not even sure my wife has the reach to both press a touchscreen in the center console and have her head in driving position to adjust the mirrors with real time feedback. Even I’d hate to have to tweak a mirror while driving with a touchscreen.

The implication is that it’s your own blood, but I like the planning/forethought. I think you’ll be going places. Probably at a run.

Feel the hate. Let it flow through you.

Not to defend them or minimize the corporate stupidity, but it sounded like there were less than 100k people affected out of tens of millions (100m?) accounts. I get that it was a big deal for those affected, but a 0.1% outage doesn’t seem “major”.

The description of an unexpected/(impossible) orientation for an on road obstacle works as an excuse, right up to the point where you realize that the software should, explicitly, not run into anything at all. That’s got to be, like, the first law of (robotic) vehicle piloting.

It was just lucky that it happened twice as, otherwise, Alphabet likely would have shrugged it off as some unimportant, random event.

I would prefer they brought back the actual shipping part. Not this $169/yr for “best effort 3-10 days depending on our mood” they want me to pay for.

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On the flip side, global banking processes something like 5+ orders of magnitude more transactions than ETH, so even at the low end it’s 1000x more efficient than the most well known POS coin.

I’m pretty sure that middle bit is like a springform pan. The handle is not solid - you squeeze it to make it sit in the waffle maker but when you remove it, it opens a bit to release. I have no room for this in my kitchen but am intensely intrigued. I might buy a new house so I can get a bigger kitchen and have a place for this.

What’s worse is when you think there’s a discussion starting because it’s “hot” and there’s a comment thread started…only to find that the only comment in the body is the summary bot.

It’s a link bot. the Reddit refugees felt it necessary to write bots to link spam lemmy so it felt busy here.

Prime used to mean something. Guaranteed 2 day shipping with no minimum for no extra charge. $5 for next day shipping. Then next day disappeared. Then the 2 day guarantee disappeared. Then delivery times were in the 3-5 day range for most things. Then, in my university town, around the time of students returning to school for terms it would be 1-2 weeks. I’m not paying an ever increasing annual fee for that.

Doubtful. 20 years in Afghanistan bought us nothing. Half a century of meddling in the rest of central America has produced refugee waves. While we could, theoretically, try to assist the Mexican government with funds we’d probably fuck that up too.

Any braking without energy recovery is wildly wasteful. Public transit (busses, trains) are fucking terrible wastes of energy due to their large mass and frequent stops. Hybrid and/or electric busses are, in this respect, potentially far superior to their diesel counterparts. I’m not a train person (engineer…train…haha) but I don’t think even the all electric trains use regenerative braking and there are few battery powered trains in service.

I’ve spent the last year altering my driving habits when I can. I try not to be an asshole when others are around/in traffic, but when I’m not pressed I will coast to a stop as much as possible (esp uphill) and use hills to gain momentum. Over 6000 miles, I’ve raised my overall mpg around 18%.

Not quite. EVs can still do door to door transport, are faster portal to portal, and have a vastly more diverse infrastructure, including the ability to (at least in a limited extent) traverse areas without track or road infrastructure. Public transit is still better, especially for rail, in reducing energy losses due to wheel deformation, reduction of human fatigue and dependence on attentiveness, and in some cases station to station speed and net air resistance per passenger mile. Since this is technology instead of fuckcars, it seems reasonable not to circlejerk too much.

In traffic, the largest reduction of efficiency comes from accelerating and the braking. You use energy to start moving (proportional to m V^2) and then you dump that energy into heat in your brakes to stop. The second comes from idling where you use energy to keep the engine rotating. As others have mentioned, EVs use regenerative braking so a substantial portion of the energy used to slow and stop the car is used to recharge the battery. EVs have no need to keep an engine running so unless you’re running the a/c there are minimal demands on a stopped/idling EV.

On the highway, you have the internal friction in the drivetrain to overcome, the constant deformation of the tires, and - most importantly - wind resistance, which is proportional to cd x rho x V2.

Cd (drag) and rho (air density) are low, but that V (speed) squared means driving at 75mph incurs 25x the energy use as driving at 15 mph. An EV gets no sage harbor here - plowing through a fluid (air) is essentially the same work.

To give you a sense of numbers, my vehicle (F150) gets less than 10mpg the 5 miles to my local pool/gym. The speed limit is 25 mph but there are stop signs every block or two. Lots of braking loss. On back roads with gentle curves and a 45 mph limit I get close to 30 mpg. That’s the sweet spot between overcoming transmission friction and air resistance. On the highway at 60 mph I get 22-23 mpg. At 78-79 mph I get 19 mpg. These are all generally on flat stretches using the 6 min average on my dashboard.

(Sorry for the long post…I’m an engineer and mechanical efficiency and aerodynamics are my happy place)

In many cases,in the US, the rack rate for a full course of a serious cancer is easily the $500k I suggested and frequently more than double that. My treatment for a suspected single point melanoma was close to $75,000 and it was a single outpatient procedure with a pre- and post-op office follow up. No chemo, no stage designation, nothing - zero cancer found at the site of the questionable biopsy site.

It’s true the Luxturna is an odd case (though the OP article is talking about customized treatment so it is appropriate here). It’s not the disease or cure but the justification of how they determined the cost of their treatment. Not based on the research cost or market, not based on the production or application of the treatment, but on the value of your eyesight they would be preserving.

Nearly all of the basic research is already taxpayer funded through research grants. There are still development costs (especially trials and such), but most of the money spent my large pharmaceutical companies goes into marketing. (it’s been a few years, but last time I looked in the mid-teens it was more than 50% of their overall budget iirc)

No it will be more expensive. The pricing would be based on how much it currently costs, priced competitively (95% of, say, $500,000) and then they’d add $500,000 to account for the fact that you would recover more of your life and avoid suffering, so $950k total. Of course they may simply price is based on the value of your life. Say the average value of a human is $1.5M in a typical wrongful death suit; they might price it at $1.25M - a bargain!.

Before you laugh at my logic, I’ll point out that Luxturna priced their retinal degeneration drug based on how much value courts placed on lost eyesight. They found that to be around the million-dollar range. The price of treatment was then set at $850,000, because that’s clearly providing value over the monetary equivalent of loss of eyesight (Jeffrey Marrazzo, CEO, was quoted in an interview that this was the basis). Of course, there’s an evilly fun MBA discussion to be had, as well, as your pricing could also be how much it’s worth to a parent not to have to watch their children slowly and unavoidably go blind as they become teenagers. Other drugs are often based on the cost avoidance or value of human life of 100-150k per year, and I’m sure they will argue that a cure should account for the entire life amortization of such a cost. Maybe it will be $5M for someone in their 20s, but only $500k for someone in their 70s.

Which is why the Moderna vaccine will be priced at just 95% of the cost of the repeat treatments and hospitalization plus the value of the time saved and pain and suffering avoidance by the patient. Say, an extra half a million. I mean, what price would you put on avoiding seeing your parent or child subjected to round after round of chemotherapy?